I saw your clips for a few days.
Your idea for the story is good that almost everybody gets insane and that the kids visit the mansion to stop this madness. I like it, really.
However: The intro is too long. You should cut the introduction a little bit, because it is an adventure game and not an interactive movie. ^^ So it could be better, if you would mention the important things of the story, so that not everybody comes to the idea to break up the opening scene. I know that you put a lot of work for these sequences and the animations look very good, but some things of the introduction are unnecessary (like the kitchen scene in Bernards house for example).
But I have still one great problem with your game: The interface. It is too complex and doesn't look really good. There are some unnecessary commands like the "follow" and the "read"-button for example. Why are these commands in the game, when you can read some signs with the "look at" - command for example? Maybe you have a reason for this, but it's so difficult for the player to solve the game, when he/she will be overtax with the interface. It would be better, if you use the old interface of DOTT for example, because it's much easier to control the characters through it.
I will watch your progress anyway. I'm looking forward for the result.